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Somnath Wable*, Trusha Shangrapawar, Ashok Bhosale
Department of Pharmaceutics, PDEA’s Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Kharadi, Pune-14, Maharashtra, India.https://doi.org/10.33786/JCPR.2019.v09i04.021
The aim of present study is to prepare gastro-retentive bilayer tablets of Losartan Potassium with an immediate release and a sustained release layer with an objective to increase gastric residence time, improve absorption, enhance the bioavailability and improve therapeutic efficacy, reduce dosage frequency. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for single drug as immediate dose and maintenance dose. The immediate release layer was prepared using super disintegrant crospovidone and sustained release layer is formulated with different polymers such as xanthum gum, guar gum and hydroxy propyl methyl cellulose K100M, individually in different concentrations and in combinations. The preformulation studies of formulations showed good flow properties and feasibility for direct compression. The compressed bilayered tablets were evaluated for hardness, friability, weight variation, drug content uniformity and in vitro drug release. Formulation contained combination of xanthum gum and guar gum was optimized which showed prolonged release of Losartan Potassium for about 24 hrs. No significant change either in physical appearance, drug content or in dissolution pattern was observed after storing at 40°C/75% relative humidity (RH) for 1 month in respect of the optimized formulation. FTIR studies revealed no chemical interaction between drug and adjuvant as well as adjuvant and adjuvant which indicates the stability of drug in tablets. The mechanism of drug release was found to be non-fickian diffusion.
Gastro retentive Drug Delivery System (GRDDS), Bilayer Technology, Bioavailability, Xanthan Gum, Guar Gum, Mucoadhesion.
The authors declare that they have no conflict of interest.
Received: 14 July 2019
Accepted: 18 August 2019