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Synthesis, and Antibacterial activities of Newer 6-(3-(1,2-dihydro-6-phenyl-2-aminopyrimidin-4-yl) phenyl amino) pyridazin-3(2H)-one


Shrikrishna Tupare*,1, Pravin Chavan2, R. P. Pawar3

1Department of Chemistry, K. E. S. Anandibai Pradhan Science College, Nagothane, Raigad- 402106, Maharashtra, India.

2Department of Chemistry, Doshi Vakil College, Goregaon-Raigad-402103, Maharashtra, India.

https://doi.org/10.33786/JCPR.2019.v09i04.027


First Online:2019-09-20

Cite As : Shrikrishna Tupare, Pravin Chavan, R. P. Pawar. 9, 4, 2019. https://doi.org/10.33786/JCPR.2019.v09i04.027

Corresponding Email id : sritupare@yahoo.com

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Abstract

Several substituted pyridazone derivative of Acetophenone are condensed with aromatic aldehydes, and resulting Chalcones are used for the synthesis of diarylpyrimidines. Organic compounds containing pyrimidines, thiopyrimidines as a core unit are known to exhibit various biological activities and pharmaceutical activities. So, all newly synthesized compounds were screened for their antibacterial activity. Most of the compounds showed significant antibacterial activities.


KEY WORDS

Pyrimidines, Guanidine, Antibacterial, Reflux.


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ACKNOWLEDGMENTS

 

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.


Copyright information

© Journal of Current Pharma Research


About this article

Received: 10 July 2019

Accepted: 27 August 2019


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