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Preparation and Characterization of Colon Targeted Drug Delivery System of Non-Steroidal Anti-inflammatory drug.

Tejas J. Vhora*, 1, Tejeswini V. Deshmukh2

1Department of Pharmaceutics, SVPM’s College of Pharmacy, Malegaon (BK II), Baramati, Pune- 413115, Maharashtra, India.

2Department of Pharmaceutics, SVPM’s College of Pharmacy, Malegaon (BK II), Baramati, Pune- 413115, Maharashtra, India.

First Online:2019-09-23

Cite As : Tejas J. Vhora, Tejeswini V. Deshmukh. 10, 1, 2019.

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Colon Targeted drug Delivery system of Mesalamine was successfully formulated by compressional coating method. Initially Mesalamine core tablets were prepared by direct compression technique and subsequently core tablets were coated by using different proportion of Eudragit RS 100 as a PH sensitive polymer and Sodium Alginate as a delayed release polymer. Mesalamine core tablets were prepared coated with polymeric coating solution. Mesalamine and excipient powdered mixture were evaluated by pre-compression parameters such as Bulk Density, Tapped Density, Hausner’s ratio, Compressibility index and Angle of Repose. Powdered mixture of core Tablet formulations were showed acceptable results for pre-compression parameters. Polymeric Coating solutions were prepared by using Sodium alginate and Eudragit RS 100. Coated tablets were evaluated by different Post-compression parameter such as Hardness, Thickness, Diameter, Appearance, Friability test etc. Disintegration test were performed for prepared Core Tablets as well as Coated Tablets by using 0.1N HCL as well as phosphate buffer PH 7.4. The Compression Coated tablets were evaluated by different IPQC and QC Tests like weight variation test, In-Vitro Dissolution study, Drug content uniformity, and stability study. All the prepared formulations shows appreciable amount of drug content and disintegration time. Drug and polymer compatibility were evaluated by FTIR study. The FTIR studies indicated that there was no interaction between drug and polymers. In In-Vitro dissolution studies different Dissolution models were studied for study of drug release kinetics of prepared optimized formulations of Colon Targeted drug delivery system. Optimized formulations F3 and F4 were showed the drug release according to First Order Model and Korsemeyer Peppas model.


pH Sensitive Drug Delivery System, Colon Targeted Drug Delivery System, Mesalamine, Mesalazine, 5-Aminosalicylic Acid.

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Not Applicable.



The authors declare that they have no conflict of interest.

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© Journal of Current Pharma Research

About this article

Received: 31 July 2019

Accepted: 18 September 2019

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