Bentham Science Logo

Analytical Method Development and Validation of RP-HPLC Method for Determination ofEletriptan HBr.


Shoaeb Mohammad Syed*,1, R. P. Marathe2, P. R. Mahaparale3

1Research Scholar, Dept of Pharmaceutics, Govt. College of Pharmacy, Opp Govt. Polytechnic, Hotel Vedant Road Osmanpura, Aurangabad, 431005, Maharashtra, India.


2Professor & Head Dept. of Pharma. Chem. Govt. College of Pharmacy, Opp Govt. Polytechnic, Hotel Vedant Road Osmanpura, Aurangabad, 431005, Maharashtra, India.


3Associate Professor & Head Dept of Pharmaceutics, Govt. College of Pharmacy, Opp Govt. Polytechnic, Hotel Vedant Road Osmanpura, Aurangabad, 431005, Maharashtra, India.

https://doi.org/10.33786/JCPR.2019.v10i01.004


First Online:2019-11-22

Cite As : Shoaeb Mohammad Syed, R. P. Marathe, P. R. Mahaparale. 10,1, 2019. https://doi.org/10.33786/JCPR.2019.v10i01.004

Corresponding Email id : ybccpsh@gmail.com

  • 191 Downloads

Abstract

The aim of recent study was to develop highly precise RP-HPLC method for estimation of eletriptan hydrobromide in pharmaceutical formulation, RP-HPLC method was developed using Alligent-1100 C18 column (Chemstation-32 software) at 300c with flow rate of 1.0ml/min. at detection wavelength of 234nm with UV visible detector. The method was validated as per ICH guidelines and various validation parameters like accuracy, precision, limit of detection (LOD), Limit of Quantification (LOQ), recovery study and range were determined. The proposed method was simple, rapid, precise, and accurate, and can be used for routine analysis of eletriptan hydrobromide in bulk and combinations the method was found to be linear in the range of 5-30 mcg/ml with coefficient relation of 0.9998.


KEY WORDS

Eletriptan HBr, RP-HPLC Method, Validation, Accuracy, Precision, LOD, LOQ.


Download Full Text Article


Notes

ACKNOWLEDGEMENT

 

ETHICAL ISSUE

Not Applicable.

 

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.


Copyright information

© Journal of Current Pharma Research


About this article

Received: 10 October 2019

Accepted: 17 November 2019


Webmaster Contact: info@e-currentscience.com
Copyright © 2018 e-currentscience.com | Privacy Policy