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Valsartan Buccal Patches- A Promising Approach to Enhance Drug Delivery.


G. D. Mehetre, R. R. Thenge, R. S. Cheke, V. N. Shrikhande

Department of Pharmaceutics, Dr. Rajendra Gode College of Pharmacy, Malkapur, Dist- Buldana, 443101 Maharashtra, India.

https://doi.org/10.33786/JCPR.2019.v10i01.006


First Online:2020-01-05

Cite As : G. D. Mehetre, R. R. Thenge, R. S. Cheke, V. N. Shrikhande. 10,1, 2019. G. D. Mehetre, R. R. Thenge, R. S. Cheke, V. N. Shrikhande

Corresponding Email id : gdm.pharma@gmail.com

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Abstract

Majority of the drugs are administered to the body with the basic aim to achieve a stable blood or tissue concentration which is therapeutically effective and nontoxic for an extended period of time. This can be achieved if proper dosage regimens are designed and attempt is made to attain a maximum rate and extent of drug absorption. By the use of new drug delivery systems, one can enhance the bioavailability and therapeutic index of medical agents as well as reduce side effects and can improve acceptance and compliance by the patients. The present work was aimed to formulate and evaluate buccoadhesive patches of Valsartan. Valsartan is an anti-hypertensive drug. Though seems an easier way, but proved very efficient to use buccal patches as drug delivery system. Suitable polymers HPMCK15, PVPK30, and PEG400 were selected as release retardants. Prepared formulations were appropriately evaluated and results analyzed. Among the various concentration of polymeric combinations, the combination ratio 2:1(HPMCK15:PVPK30) was found to be most suitable. The formulation R6 combination of polymers HPMCK15, PVPK30 fulfills the requirement of good buccal patches. It showed highest drug release up to 95.29% for 12hr. Preformulation and formulation results revealed that the buccal patches incorporated with valsartan proved to be a highly efficient drug delivery system showing improved release characteristics. The release analysis revealed diffusion mediated drug release following Higuchian model. Concluded the formulation as one desired and acceptable.


KEY WORDS

Valsartan, HPMC, PVP, PEG, buccal patches.


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Notes

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.


Copyright information

© Journal of Current Pharma Research


About this article

Received: 24 November 2019

Accepted: 28 December 2019


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