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Anjali R. Kale*, Sujit Kakade, Ashok Bhosale
PDEA’s Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Kharadi,
Pune-14, Maharashtra, India.
A drug administered within the form of solubility at once available for absorption and with efficiency absorbed than a similar quantity of drug administered during a pill or capsule kind. Solubility for oral bioavailability of poorly soluble drugs is most important. Solubility is one of the parameters to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Rate determining step of dissolution drug for oral absorption of poorly or less water soluble drug that affect of in vivo absorption of drug. Currently only 8% of new drug candidates have both high solubility and high permeability. Poorly water soluble has require high dose in oral administration before reach in plasma concentration. The major problem is low aqueous solubility similar with formulation development of new chemical entities. Any drug to be absorbed should be present within the form of associate solution at the site of absorption. Water is the solvent of choice for liquid pharmaceutical formulations. Most of drugs has weakly acidic and basic with poor aqueous solubility. Because of solubility enhancement is necessary because many drugs solubility affect on bioavailability of drug. Now solubility is increase with the help of various techniques like Cocrystallization, co-solvency, hydrotrophy, PH adjustment, nanotechnology approaches and solid dispersion technique.
Solubility, Solubility Enhancement, Dissolution, Bioavailability.
CONFLICT OF INTEREST
The authors declare that they have no conflict of interest.
Received: 22 November 2019
Accepted: 14 January 2020