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Fabrication and in-vitro evaluation of valsartan nanosuspensions.


Haritha Meda*,1, Devala Rao G.2, Harini Chowdary V.3, Mandava Bhuvan Tej4

1Department of Pharmaceutical Sciences, Krishna University, Machilipatnam-521001, India.

2KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India.

3Department of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, Bengaluru-560107, India.

4Sri Ramachandra College of Pharmacy, Porur, Chennai-600116, Tamilnadu, India.

https://doi.org/10.33786/JCPR.2020.v10i03.003


First Online:2020-03-22

Cite As : Haritha Meda, Devala Rao G., Harini Chowdary V., Mandava Bhuvan Tej. https://doi.org/10.33786/JCPR.2020.v10i03.003

Corresponding Email id : medaharitha777@gmail.com

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Abstract

The rationale of the present study was to formulate, characterize and evaluate the nanosuspension of valsartan, a poorly water soluble and low bioavailable drug with intend of recuperating aqueous solubility consequently the dissolution rate. Valsartan nanosuspensions were prepared by solvent evaporation method using different polymers. Materials used in the preparation of nanosuspensions were Tween80, Polaxomer, PVP-K90, PVA, and Ethanol. Different ratio of polymers were used in the formulation of twelve valsartan formulations (VF1 to VF12) The prepared nanosuspensions were characterized by drug- excipient interactions (FTIR) and evaluated for drug content uniformity, particle size analysis, zeta potential, in-vitro drug release and short-term stability. VF11 formulation exhibited 99.86% of drug released within 25 min and exhibited zero order drug release kinetics. Stability studies indicated VF11 formulation exhibited better stability.


KEY WORDS

Nanosuspension, solvent evaporation, zeta potential, polymers, particle size.


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Notes

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.


Copyright information

© Journal of Current Pharma Research


About this article

Received: 31 December 2019

Accepted: 16 February 2020


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