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Haritha Meda*,1, Devala Rao G.2, Harini Chowdary V.3, Mandava Bhuvan Tej4
1Department of Pharmaceutical Sciences, Krishna University, Machilipatnam-521001, India.
2KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India.
3Department of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, Bengaluru-560107, India.
4Sri Ramachandra College of Pharmacy, Porur, Chennai-600116, Tamilnadu, India.https://doi.org/10.33786/JCPR.2020.v10i03.003
The rationale of the present study was to formulate, characterize and evaluate the nanosuspension of valsartan, a poorly water soluble and low bioavailable drug with intend of recuperating aqueous solubility consequently the dissolution rate. Valsartan nanosuspensions were prepared by solvent evaporation method using different polymers. Materials used in the preparation of nanosuspensions were Tween80, Polaxomer, PVP-K90, PVA, and Ethanol. Different ratio of polymers were used in the formulation of twelve valsartan formulations (VF1 to VF12) The prepared nanosuspensions were characterized by drug- excipient interactions (FTIR) and evaluated for drug content uniformity, particle size analysis, zeta potential, in-vitro drug release and short-term stability. VF11 formulation exhibited 99.86% of drug released within 25 min and exhibited zero order drug release kinetics. Stability studies indicated VF11 formulation exhibited better stability.
Nanosuspension, solvent evaporation, zeta potential, polymers, particle size.
CONFLICT OF INTEREST
The authors declare that they have no conflict of interest.
Received: 31 December 2019
Accepted: 16 February 2020